Hydroxyamine hydrochloride → HCID 58043489, compound

HRID 1617781Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([C:20]1[CH:21]=[CH:22][C:23](=[O:27])[N:24]([CH3:26])[CH:25]=1)[CH2:9][C:10]([C:12]1[CH:13]=[CH:14][C:15](=[O:19])[N:16]([CH3:18])[CH:17]=1)=O.Cl.[NH2:29][OH:30].C([O-])(O)=O.[Na+]>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([C:20]1[CH:21]=[CH:22][C:23](=[O:27])[N:24]([CH3:26])[CH:25]=1)[CH2:9]/[C:10](/[C:12]1[CH:13]=[CH:14][C:15](=[O:19])[N:16]([CH3:18])[CH:17]=1)=[N:29]\[OH:30]

Participants

Reactant 3

HCID 443297Hydroxyamine hydrochloride

HCID 516892Sodium Bicarbonate

HCID 67015630HCID 67015630, compound

Product 1

HCID 58043489HCID 58043489, compound

Procedure

In analogy to example 151, step 3, 5,5′-[1-(2-chlorophenyl)-3-oxopropane-1,3-diyl]bis(1-methylpyridin-2(1H)-one) was reacted with hydroxylamine hydrochloride in the presence of NaHCO3 to give the title compound containing less than 10% of the corresponding Z isomer as an off-white solid, MS (ESI+): m/z=398.1 [M+H]+.

Sources & evidence

ORD record: ord-bab77448be4b4aaf967fe6d9e5aded92
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08765730B2

Reaction notes

Loading…