Hydroxyamine hydrochloride → HCID 136167012, compound

HRID 1617791Notes

Reaction equation

HRID 1617791 reaction equation
[OH:1][CH2:2][CH:3]1[CH2:8][CH2:7][N:6]([C:9]2[CH:14]=[CH:13][C:12]([C@H:15]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[CH3:32])[CH2:16][C:17]([C:19]3[CH:24]=[CH:23][N:22]=[C:21]([CH3:25])[CH:20]=3)=O)=[CH:11][CH:10]=2)[CH2:5][CH2:4]1.Cl.[NH2:34][OH:35].C([O-])(O)=O.[Na+]>>[OH:1][CH2:2][CH:3]1[CH2:8][CH2:7][N:6]([C:9]2[CH:14]=[CH:13][C:12]([C@H:15]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[CH3:32])[CH2:16]/[C:17](/[C:19]3[CH:24]=[CH:23][N:22]=[C:21]([CH3:25])[CH:20]=3)=[N:34]\[OH:35])=[CH:11][CH:10]=2)[CH2:5][CH2:4]1

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 67015623HCID 67015623, compound

Product 1

HCID 136167012HCID 136167012, compound

Procedure

In analogy to example 132, step 6, from (R)-3-[4-(4-hydroxymethyl-piperidin-1-yl)-phenyl]-1-(2-methyl-pyridin-4-yl)-3-o-tolyl-propan-1-one and hydroxylamine hydrochloride in the presence of NaHCO3 was prepared the title compound as a colorless oil, MS (ESI+): m/z=444.4 ([M+H]+).

Sources & evidence

ORD record
ord-b53dea88e3d44739986b79b7a7f77c16
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

Loading…