Hydroxyamine hydrochloride → HCID 136166963, compound

HRID 1617792Notes

Reaction equation

[CH3:1][O:2][CH:3]1[CH2:6][N:5]([C:7]2[CH:12]=[CH:11][C:10]([C@H:13]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=3[CH3:30])[CH2:14][C:15]([C:17]3[CH:22]=[CH:21][N:20]=[C:19]([CH3:23])[CH:18]=3)=O)=[CH:9][CH:8]=2)[CH2:4]1.Cl.[NH2:32][OH:33].C([O-])(O)=O.[Na+]>>[CH3:1][O:2][CH:3]1[CH2:4][N:5]([C:7]2[CH:8]=[CH:9][C:10]([C@H:13]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=3[CH3:30])[CH2:14]/[C:15](/[C:17]3[CH:22]=[CH:21][N:20]=[C:19]([CH3:23])[CH:18]=3)=[N:32]\[OH:33])=[CH:11][CH:12]=2)[CH2:6]1

Participants

Reactant 3

HCID 443297Hydroxyamine hydrochloride

HCID 516892Sodium Bicarbonate

HCID 67015637HCID 67015637, compound

Product 1

HCID 136166963HCID 136166963, compound

Procedure

In analogy to example 1, step 2, from (R)-3-[4-(3-methoxy-azetidin-1-yl)-phenyl]-1-(2-methyl-pyridin-4-yl)-3-o-tolyl-propan-1-one and hydroxylamine hydrochloride in the presence of NaHCO3 was prepared the title compound as a white foam, MS (ESI+): m/z=416.3 ([M+H]+.

Sources & evidence

ORD record: ord-d6a97416aad34180a7e58e1cb1cedb77
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08765730B2

Reaction notes

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