Hydroxyamine hydrochloride → HCID 136167010, compound

HRID 1617793Notes

Reaction equation

HRID 1617793 reaction equation
[O:1]=[S:2]1(=[O:32])[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][C:11]([C@H:14]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[CH3:31])[CH2:15][C:16]([C:18]3[CH:23]=[CH:22][N:21]=[C:20]([CH3:24])[CH:19]=3)=O)=[CH:10][CH:9]=2)[CH2:4][CH2:3]1.Cl.[NH2:34][OH:35].C([O-])(O)=O.[Na+]>>[O:1]=[S:2]1(=[O:32])[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][C:11]([C@H:14]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[CH3:31])[CH2:15]/[C:16](/[C:18]3[CH:23]=[CH:22][N:21]=[C:20]([CH3:24])[CH:19]=3)=[N:34]\[OH:35])=[CH:10][CH:9]=2)[CH2:4][CH2:3]1

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 66669262HCID 66669262, compound

Product 1

HCID 136167010HCID 136167010, compound

Procedure

In analogy to example 132, step 6, from (R)-3-[4-(1,1-dioxo-1lambda6-thiomorpholin-4-yl)-phenyl]-1-(2-methyl-pyridin-4-yl)-3-o-tolyl-propan-1-one and hydroxylamine hydrochloride in the presence of NaHCO3 was prepared the title compound as a light yellow foam, MS (ESI+): m/z=464.2 ([M+H]+).

Sources & evidence

ORD record
ord-e88c8449806c42cb8898c29bde1988e9
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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