Lithium Hydroxide → HCID 66666235, compound

HRID 1617807Notes

Reaction equation

C[O:2][C:3](=[O:29])[C:4]1[CH:9]=[CH:8][C:7]([C@@H:10]([C:21]2[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][C:22]=2[CH3:28])[CH2:11][C:12]([C:14]2[CH:19]=[CH:18][N:17]=[C:16]([CH3:20])[CH:15]=2)=[O:13])=[CH:6][CH:5]=1.[OH-].[Li+]>>[Cl:27][C:24]1[CH:25]=[CH:26][C:21]([C@H:10]([C:7]2[CH:6]=[CH:5][C:4]([C:3]([OH:29])=[O:2])=[CH:9][CH:8]=2)[CH2:11][C:12]([C:14]2[CH:19]=[CH:18][N:17]=[C:16]([CH3:20])[CH:15]=2)=[O:13])=[C:22]([CH3:28])[CH:23]=1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 66667005HCID 66667005, compound

Product 1

HCID 66666235HCID 66666235, compound

Procedure

In analogy to example 272, step 2, from 4-[(S)-1-(4-chloro-2-methyl-phenyl)-3-(2-methyl-pyridin-4-yl)-3-oxo-propyl]-benzoic acid methyl ester in presence of 1 M aq. lithium hydroxide solution was prepared the title compound as an off-white solid, MS (ESI−): m/z=392.0 ([M−H]−).

Sources & evidence

ORD record: ord-8be98cd9052c4c178778ab830a2a8cca
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08765730B2

Reaction notes

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