反应详情

To a solution of (R)-1-(2-methyl-pyridin-4-yl)-3-o-tolyl-3-(4-trimethylsilanylethynyl-phenyl)-propan-1-one (100 mg) in methanol (5 mL) was added at 0° C. potassium carbonate (3.4 mg). The reaction mixture was stirred at room temperature for 20 h. A saturated aq. solution of ammonium chloride and ethyl acetate were added, the phases were separated and the inorganic one was extracted with ethyl acetate (2×). The combined organic layers were washed with brine, dried over sodium sulfate, filtered and concentrated in vacuo. The crude product was purified by flash chromatography on silica gel (15% to 50% ethyl acetate in n-heptane) to yield the title compound as a colourless oil (60 mg, 95%), MS (ESI+): m/z=340.2 ([M+H]+).

1. customthe phases were separated
2. extractionthe inorganic one was extracted with ethyl acetate (2×)
3. washThe combined organic layers were washed with brine
4. dry with materialdried over sodium sulfate
5. filtrationfiltered
6. concentrationconcentrated in vacuo
7. customThe crude product was purified by flash chromatography on silica gel (15% to 50% ethyl acetate in n-heptane)