Diisopropylethylamine → HCID 86661104, compound

HRID 1617823Notes

Reaction equation

[Li+].CON(C)[C:5]([CH2:7][C@H:8]([C:16]1[CH:21]=[CH:20][C:19]([C:22]2[CH:27]=[CH:26][C:25]([C:28]([O-:30])=[O:29])=[CH:24][CH:23]=2)=[CH:18][CH:17]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[CH3:15])=[O:6].[Cl:32][C:33]1[CH:38]=[C:37](I)[CH:36]=[CH:35][N:34]=1.C(N(CC)C(C)C)(C)C>>[Cl:32][C:33]1[CH:38]=[C:37]([C:5](=[O:6])[CH2:7][C@H:8]([C:16]2[CH:21]=[CH:20][C:19]([C:22]3[CH:23]=[CH:24][C:25]([C:28]([OH:30])=[O:29])=[CH:26][CH:27]=3)=[CH:18][CH:17]=2)[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[CH3:15])[CH:36]=[CH:35][N:34]=1

Participants

Reactant 3

HCID 81531Diisopropylethylamine

HCID 15165112-Chloro-4-iodopyridine

HCID 87096799HCID 87096799, compound

Product 1

HCID 86661104HCID 86661104, compound

Procedure

In analogy to example 74, step 5, from 4′-[(R)-2-(methoxy-methyl-carbamoyl)-1-o-tolyl-ethyl]-biphenyl-4-carboxylic acid lithium salt, 2-chloro-4-iodopyridine and N,N-diisopropyl-ethylamine was prepared the title compound as a brown foam, MS (ESI−): m/z=454.1 [M−H]−.

Sources & evidence

ORD record: ord-20fafc94eb4b4c35b63cd2d5aa9a78bf
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08765730B2

Reaction notes

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