Hydroxyamine hydrochloride → HCID 136167079, compound

HRID 1617825Notes

Reaction equation

HRID 1617825 reaction equation
O=[C:2]([C:27]1[CH:32]=[CH:31][N:30]=[C:29]([C:33]([F:36])([F:35])[F:34])[CH:28]=1)[CH2:3][C@H:4]([C:12]1[CH:17]=[CH:16][C:15]([C:18]2[CH:23]=[CH:22][C:21]([C:24]([OH:26])=[O:25])=[CH:20][CH:19]=2)=[CH:14][CH:13]=1)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[CH3:11].Cl.[NH2:38][OH:39].C(=O)([O-])O.[Na+]>>[OH:39]/[N:38]=[C:2](/[C:27]1[CH:32]=[CH:31][N:30]=[C:29]([C:33]([F:35])([F:34])[F:36])[CH:28]=1)\[CH2:3][C@H:4]([C:12]1[CH:17]=[CH:16][C:15]([C:18]2[CH:19]=[CH:20][C:21]([C:24]([OH:26])=[O:25])=[CH:22][CH:23]=2)=[CH:14][CH:13]=1)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[CH3:11]

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 66666763HCID 66666763, compound

Product 1

HCID 136167079HCID 136167079, compound

Procedure

In analogy to example 132, step 6, from 4′-[(R)-3-oxo-1-o-tolyl-3-(2-trifluoromethyl-pyridin-4-yl)-propyl]-biphenyl-4-carboxylic acid and hydroxylamine hydrochloride in the presence of sodium hydrogencarbonate was prepared the title compound as a light brown foam, MS (ESI−): m/z=503.0 ([M−H]−).

Sources & evidence

ORD record
ord-0e0ed544926b4da0b8504cfa7610cc42
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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