Hydroxyamine hydrochloride → HCID 136167078, compound

HRID 1617827Notes

Reaction equation

HRID 1617827 reaction equation
[Cl:1][C:2]1[C:3]([C:9](=O)[CH2:10][C@H:11]([C:19]2[CH:24]=[CH:23][C:22]([C:25]3[CH:30]=[CH:29][C:28]([C:31]([OH:33])=[O:32])=[CH:27][CH:26]=3)=[CH:21][CH:20]=2)[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[CH3:18])=[CH:4][C:5]([F:8])=[N:6][CH:7]=1.Cl.[NH2:36][OH:37].C(=O)([O-])O.[Na+]>>[Cl:1][C:2]1[C:3](/[C:9](=[N:36]/[OH:37])/[CH2:10][C@H:11]([C:19]2[CH:24]=[CH:23][C:22]([C:25]3[CH:30]=[CH:29][C:28]([C:31]([OH:33])=[O:32])=[CH:27][CH:26]=3)=[CH:21][CH:20]=2)[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[CH3:18])=[CH:4][C:5]([F:8])=[N:6][CH:7]=1

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 66666579HCID 66666579, compound

Product 1

HCID 136167078HCID 136167078, compound

Procedure

In analogy to example 132, step 6, from 4′-[(R)-3-(5-chloro-2-fluoro-pyridin-4-yl)-3-oxo-1-o-tolyl-propyl]-biphenyl-4-carboxylic acid and hydroxylamine hydrochloride in the presence of sodium hydrogencarbonate was prepared the title compound as a light yellow oil, MS (ESI−): m/z=487.3 ([M−H]−).

Sources & evidence

ORD record
ord-4b7121949e534be69f6a5f023586ad53
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

Loading…