Hydroxyamine hydrochloride → HCID 58043412, compound

HRID 1617860Notes

Reaction equation

HRID 1617860 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:20]2[CH:31]=[CH:30][C:23]([C:24]([NH:26][CH2:27][CH2:28][OH:29])=[O:25])=[CH:22][CH:21]=2)[CH2:9][C:10]([C:12]2[CH:17]=[CH:16][C:15](=[O:18])[N:14]([CH3:19])[CH:13]=2)=O)=[C:4]([F:32])[CH:3]=1.Cl.[NH2:34][OH:35].C(=O)([O-])O.[Na+]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:20]2[CH:21]=[CH:22][C:23]([C:24]([NH:26][CH2:27][CH2:28][OH:29])=[O:25])=[CH:30][CH:31]=2)[CH2:9]/[C:10](=[N:34]\[OH:35])/[C:12]2[CH:17]=[CH:16][C:15](=[O:18])[N:14]([CH3:19])[CH:13]=2)=[C:4]([F:32])[CH:3]=1

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 66668154HCID 66668154, compound

Product 1

HCID 58043412HCID 58043412, compound

Procedure

In analogy to example 151, step 3, 4-[1-(4-chloro-2-fluoro-phenyl)-3-(1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)-3-oxo-propyl]-N-(2-hydroxy-ethyl)-benzamide was reacted with hydroxylamine hydrochloride in the presence of sodium hydrogencarbonate to give the title compound as a colourless foam containing 7% of the corresponding Z isomer, MS (ESI+): m/z=472.2 [M+H]+.

Sources & evidence

ORD record
ord-8b2444711ea44d4e95261d77c8ca4d7a
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

Loading…