Hydrochloric Acid → HCID 66668328, compound

HRID 1617865Notes

Reaction equation

HRID 1617865 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5](/[CH:8]=[CH:9]/[C:10]([C:12]2[CH:13]=[N:14][C:15]([O:18]C)=[CH:16][CH:17]=2)=[O:11])=[C:4]([F:20])[CH:3]=1.Cl>O1CCOCC1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5](/[CH:8]=[CH:9]/[C:10]([C:12]2[CH:17]=[CH:16][C:15](=[O:18])[NH:14][CH:13]=2)=[O:11])=[C:4]([F:20])[CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67015779HCID 67015779, compound

Product 1

HCID 66668328HCID 66668328, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

In analogy to example 162, step 2, (E)-3-(4-chloro-2-fluorophenyl)-1-(6-methoxypyridin-3-yl)prop-2-en-1-one (example 237, step 1) was reacted with concentrated aqueous HCl in 1,4-dioxane to give the title compound as an colourless solid, MS (ESI+): m/z=278.0 [M+H]+.

Sources & evidence

ORD record
ord-e0af8e3cb0134a1396ebedc37a565202
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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