Methyl iodide → HCID 66668501, compound

HRID 1617866Notes

Reaction equation

HRID 1617866 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5](/[CH:8]=[CH:9]/[C:10]([C:12]2[CH:13]=[CH:14][C:15](=[O:18])[NH:16][CH:17]=2)=[O:11])=[C:4]([F:19])[CH:3]=1.IC.[C:22](=O)([O-])[O-].[K+].[K+]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5](/[CH:8]=[CH:9]/[C:10]([C:12]2[CH:13]=[CH:14][C:15](=[O:18])[N:16]([CH3:22])[CH:17]=2)=[O:11])=[C:4]([F:19])[CH:3]=1

Participants

4

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 66668328HCID 66668328, compound

Product 1

HCID 66668501HCID 66668501, compound

Procedure

In analogy to example 161, step 1, (E)-5-(3-(4-chloro-2-fluorophenyl)acryloyl)pyridin-2(1H)-one was reacted with iodomethane in the presence of potassium carbonate to give the title compound as a yellow solid, MS (ESI+): m/z=292.0 [M+H]+.

Sources & evidence

ORD record
ord-b961689a6c08485aa3886ec0807ea34d
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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