Hydrochloric Acid → HCID 66666764, compound

HRID 1617878Notes

Reaction equation

HRID 1617878 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:20]2[CH:21]=[C:22]([CH:28]=[CH:29][CH:30]=2)[C:23]([O:25][CH2:26][CH3:27])=[O:24])[CH2:9][C:10]([C:12]2[CH:13]=[N:14][C:15]([O:18]C)=[CH:16][CH:17]=2)=[O:11])=[C:4]([F:31])[CH:3]=1.Cl>O1CCOCC1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:20]2[CH:21]=[C:22]([CH:28]=[CH:29][CH:30]=2)[C:23]([O:25][CH2:26][CH3:27])=[O:24])[CH2:9][C:10](=[O:11])[C:12]2[CH:17]=[CH:16][C:15](=[O:18])[NH:14][CH:13]=2)=[C:4]([F:31])[CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66666270HCID 66666270, compound

Product 1

HCID 66666764HCID 66666764, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

In analogy to example 162, step 2, ethyl 3-(1-(4-chloro-2-fluorophenyl)-3-(6-methoxy-pyridin-3-yl)-3-oxopropyl)benzoate was reacted with concentrated aqueous HCl in 1,4-dioxane to give the title compound as an colourless solid, MS (ESI+): m/z=426.0 [M+H]+.

Sources & evidence

ORD record
ord-003b46cb35e04f9e88c729ae6f4afd46
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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