Methyl iodide → HCID 67015625, compound

HRID 1617879Notes

Reaction equation

HRID 1617879 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:19]2[CH:20]=[C:21]([CH:27]=[CH:28][CH:29]=2)[C:22]([O:24][CH2:25][CH3:26])=[O:23])[CH2:9][C:10](=[O:18])[C:11]2[CH:16]=[CH:15][C:14](=[O:17])[NH:13][CH:12]=2)=[C:4]([F:30])[CH:3]=1.IC.[C:33](=O)([O-])[O-].[K+].[K+]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:19]2[CH:20]=[C:21]([CH:27]=[CH:28][CH:29]=2)[C:22]([O:24][CH2:25][CH3:26])=[O:23])[CH2:9][C:10]([C:11]2[CH:16]=[CH:15][C:14](=[O:17])[N:13]([CH3:33])[CH:12]=2)=[O:18])=[C:4]([F:30])[CH:3]=1

Participants

4

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 66666764HCID 66666764, compound

Product 1

HCID 67015625HCID 67015625, compound

Procedure

In analogy to example 161, step 1, ethyl 3-(1-(4-chloro-2-fluorophenyl)-3-oxo-3-(6-oxo-1,6-dihydropyridin-3-yl)propyl)benzoate was reacted with iodomethane in the presence of potassium carbonate to give the title compound as a colourless foam, MS (ESI+): m/z=442.2 [M+H]+.

Sources & evidence

ORD record
ord-f4c3a7ef1ce44ef78b988af6888e5b5a
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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