Hydrochloric Acid → (E)-5-(3-(2,5-dichlorophenyl)acryloyl)pyridin-2(1H)-one

HRID 1617941Notes

Reaction equation

HRID 1617941 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1/[CH:9]=[CH:10]/[C:11]([C:13]1[CH:14]=[N:15][C:16]([O:19]C)=[CH:17][CH:18]=1)=[O:12].Cl>O1CCOCC1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1/[CH:9]=[CH:10]/[C:11]([C:13]1[CH:18]=[CH:17][C:16](=[O:19])[NH:15][CH:14]=1)=[O:12]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66666230HCID 66666230, compound

Product 1

HCID 66668831(E)-5-(3-(2,5-dichlorophenyl)acryloyl)pyridin-2(1H)-one

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

In analogy to example 162, step 2, (E)-3-(2,5-dichlorophenyl)-1-(6-methoxypyridin-3-yl)prop-2-en-1-one was reacted with concentrated aqueous HCl in 1,4-dioxane to give the title compound as a light yellow solid, MS (ESI+): m/z=294.0 [M+H]+.

Sources & evidence

ORD record
ord-6c102a0e6b2a49f68409949f25e1e898
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

Loading…