Methyl iodide → (E)-5-(3-(2,5-Dichlorophenyl)acryloyl)-1-methylpyridin-2(1H)-one

HRID 1617942Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1/[CH:9]=[CH:10]/[C:11]([C:13]1[CH:14]=[CH:15][C:16](=[O:19])[NH:17][CH:18]=1)=[O:12].IC.[C:22](=O)([O-])[O-].[K+].[K+]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1/[CH:9]=[CH:10]/[C:11]([C:13]1[CH:14]=[CH:15][C:16](=[O:19])[N:17]([CH3:22])[CH:18]=1)=[O:12]

Participants

Reactant 3

HCID 6328Methyl iodide

HCID 11430Potassium Carbonate

HCID 66668831(E)-5-(3-(2,5-dichlorophenyl)acryloyl)pyridin-2(1H)-one

Product 1

HCID 66668982(E)-5-(3-(2,5-Dichlorophenyl)acryloyl)-1-methylpyridin-2(1H)-one

Procedure

In analogy to example 161, step 1, (E)-5-(3-(2,5-dichlorophenyl)acryloyl)pyridin-2(1H)-one was reacted with iodomethane in the presence of potassium carbonate to give the title compound as a light yellow solid.

Sources & evidence

ORD record: ord-cdf6892a685a4cc69e8377eb7e2d5b9a
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08765730B2

Reaction notes

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