Methyl iodide → HCID 66668223, compound

HRID 1617947Notes

Reaction equation

HRID 1617947 reaction equation
[F:1][C:2]1[CH:3]=[C:4](/[CH:9]=[CH:10]/[C:11]([C:13]2[CH:14]=[CH:15][C:16](=[O:19])[NH:17][CH:18]=2)=[O:12])[CH:5]=[C:6]([F:8])[CH:7]=1.IC.[C:22](=O)([O-])[O-].[K+].[K+]>>[F:8][C:6]1[CH:5]=[C:4](/[CH:9]=[CH:10]/[C:11]([C:13]2[CH:14]=[CH:15][C:16](=[O:19])[N:17]([CH3:22])[CH:18]=2)=[O:12])[CH:3]=[C:2]([F:1])[CH:7]=1

Participants

4

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 66668187HCID 66668187, compound

Product 1

HCID 66668223HCID 66668223, compound

Procedure

In analogy to example 161, step 1, (E)-5-(3-(3,5-difluorophenyl)acryloyl)pyridin-2(1H)-one was reacted with iodomethane in the presence of potassium carbonate to give the title compound as a light yellow solid. MS (ESI+): m/z=276.1 [M+H]+.

Sources & evidence

ORD record
ord-2ce3829055a845fba239d2183d06566b
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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