Hydroxyamine hydrochloride → HCID 136360064, compound

HRID 1617969Notes

Reaction equation

[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([C@H:10]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2[CH3:27])[CH2:11][C:12]([C:14]2[CH:19]=[CH:18][N:17]=[C:16]([CH3:20])[CH:15]=2)=O)=[CH:6][CH:5]=1)[CH3:2].Cl.[NH2:29][OH:30].C(=O)([O-])O.[Na+]>>[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([C@H:10]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2[CH3:27])[CH2:11][C:12]([C:14]2[CH:19]=[CH:18][N:17]=[C:16]([CH3:20])[CH:15]=2)=[N:29][OH:30])=[CH:6][CH:5]=1)[CH3:2]

Participants

Reactant 3

HCID 443297Hydroxyamine hydrochloride

HCID 516892Sodium Bicarbonate

HCID 67015674HCID 67015674, compound

Product 1

HCID 136360064HCID 136360064, compound

Procedure

In analogy to example 132, step 6, from (R)-3-(4-ethoxy-phenyl)-1-(2-methyl-pyridin-4-yl)-3-o-tolyl-propan-1-one and hydroxylamine hydrochloride in the presence of sodium hydrogencarbonate was prepared the title compound as a white foam, MS (ESI+): m/z=375.2 ([M+H]+).

Sources & evidence

ORD record: ord-233553e15c7947109e73f0b52d2c1035
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08765730B2

Reaction notes

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