Hydroxyamine hydrochloride → HCID 136360065, compound

HRID 1617971Notes

Reaction equation

HRID 1617971 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]([C:19]2[CH:24]=[CH:23][C:22]([OH:25])=[CH:21][CH:20]=2)[CH2:9][C:10]([C:12]2[CH:17]=[CH:16][N:15]=[C:14]([CH3:18])[CH:13]=2)=O)=[C:4]([CH3:26])[CH:3]=1.Cl.[NH2:28][OH:29].C(=O)([O-])O.[Na+]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]([C:19]2[CH:24]=[CH:23][C:22]([OH:25])=[CH:21][CH:20]=2)[CH2:9][C:10]([C:12]2[CH:17]=[CH:16][N:15]=[C:14]([CH3:18])[CH:13]=2)=[N:28][OH:29])=[C:4]([CH3:26])[CH:3]=1

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 67015669HCID 67015669, compound

Product 1

HCID 136360065HCID 136360065, compound

Procedure

In analogy to example 132, step 6, from (S)-3-(4-chloro-2-methyl-phenyl)-3-(4-hydroxy-phenyl)-1-(2-methyl-pyridin-4-yl)-propan-1-one and hydroxylamine hydrochloride in the presence of sodium hydrogencarbonate was prepared the title compound as a light yellow foam, MS (ESI+): m/z=381.2 ([M+H]+).

Sources & evidence

ORD record
ord-d0feb2107eb549b39057ae11210448a1
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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