Hydroxyamine hydrochloride → HCID 136167022, compound

HRID 1617978Notes

Reaction equation

HRID 1617978 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([C:8](=O)[CH2:9][C@H:10]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[CH3:17])[CH:5]=[CH:4][N:3]=1.Cl.[NH2:26][OH:27].C(=O)([O-])O.[Na+]>>[CH3:1][C:2]1[CH:7]=[C:6](/[C:8](=[N:26]/[OH:27])/[CH2:9][C@H:10]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[CH3:17])[CH:5]=[CH:4][N:3]=1

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 67015694HCID 67015694, compound

Product 1

HCID 136167022HCID 136167022, compound

Procedure

In analogy to example 132, step 6, from (R)-1-(2-methylpyridin-4-yl)-3-phenyl-3-o-tolylpropan-1-one and hydroxylamine hydrochloride in the presence of sodium hydrogencarbonate was prepared the title compound as a colourless oil, MS (ESI+): m/z=331.2 ([M+H]+).

Sources & evidence

ORD record
ord-7fefb2b53faf46a18b2eb52a76f7a9d8
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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