Hydroxyamine hydrochloride → HCID 136167034, compound

HRID 1617986Notes

Reaction equation

HRID 1617986 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([C:8](=O)[CH2:9][C@H:10]([C:18]2[CH:23]=[CH:22][C:21]([C:24]3[CH2:25][CH2:26][N:27]([S:30]([CH3:33])(=[O:32])=[O:31])[CH2:28][CH:29]=3)=[CH:20][CH:19]=2)[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[CH3:17])[CH:5]=[CH:4][N:3]=1.Cl.[OH:36][NH2:37].C(=O)([O-])O.[Na+]>>[CH3:1][C:2]1[CH:7]=[C:6](/[C:8](=[N:37]/[OH:36])/[CH2:9][C@H:10]([C:18]2[CH:23]=[CH:22][C:21]([C:24]3[CH2:25][CH2:26][N:27]([S:30]([CH3:33])(=[O:32])=[O:31])[CH2:28][CH:29]=3)=[CH:20][CH:19]=2)[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[CH3:17])[CH:5]=[CH:4][N:3]=1

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 66668997HCID 66668997, compound

Product 1

HCID 136167034HCID 136167034, compound

Procedure

In analogy to example 132, step 6, from (R)-1-(2-methylpyridin-4-yl)-3-(4-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)-3-o-tolylpropan-1-one and hydroxyl-amine hydrochloride in the presence of sodium hydrogencarbonate was prepared the title compound as a colourless foam, MS (ESI+): m/z=490.4 ([M+H]+).

Sources & evidence

ORD record
ord-d416eee1251b435b84913a8772056fa8
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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