Hydroxyamine hydrochloride → HCID 178426103, compound

HRID 1617995Notes

Reaction equation

HRID 1617995 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]([C:20]2[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][C:21]=2[CH3:27])[CH2:9][C:10]([C:12]2[CH:17]=[CH:16][N+:15]([O-:18])=[C:14]([CH3:19])[CH:13]=2)=O)=[CH:4][CH:3]=1.Cl.[NH2:29][OH:30].C(=O)([O-])O.[Na+]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]([C:20]2[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][C:21]=2[CH3:27])[CH2:9]/[C:10](/[C:12]2[CH:17]=[CH:16][N+:15]([O-:18])=[C:14]([CH3:19])[CH:13]=2)=[N:29]\[OH:30])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 66666645HCID 66666645, compound

Product 1

HCID 178426103HCID 178426103, compound

Procedure

In analogy to example 132, step 6, from (R)-4-(3-(4-bromophenyl)-3-(4-chloro-2-methyl-phenyl)propanoyl)-2-methylpyridine 1-oxide (example 383, step 1) and hydroxylamine hydrochloride in the presence of sodium hydrogencarbonate was prepared the title compound as a white foam, MS (ESI+): m/z=459.1 ([M+H]+).

Sources & evidence

ORD record
ord-38f073459a1f409eb9cb582709ede34e
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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