Hydroxyamine hydrochloride → HCID 136166937, compound

HRID 1618001Notes

Reaction equation

HRID 1618001 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([C:19]2[CH:24]=[CH:23][C:22]([CH:25]3[CH2:30][CH2:29][N:28]([S:31]([CH3:34])(=[O:33])=[O:32])[CH2:27][CH2:26]3)=[CH:21][CH:20]=2)[CH2:9][C:10]([C:12]2[CH:17]=[CH:16][N:15]=[C:14]([CH3:18])[CH:13]=2)=O)=[C:4]([CH3:35])[CH:3]=1.Cl.[NH2:37][OH:38].C(=O)([O-])O.[Na+]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([C:19]2[CH:24]=[CH:23][C:22]([CH:25]3[CH2:30][CH2:29][N:28]([S:31]([CH3:34])(=[O:33])=[O:32])[CH2:27][CH2:26]3)=[CH:21][CH:20]=2)[CH2:9]/[C:10](/[C:12]2[CH:17]=[CH:16][N:15]=[C:14]([CH3:18])[CH:13]=2)=[N:37]\[OH:38])=[C:4]([CH3:35])[CH:3]=1

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 67015687HCID 67015687, compound

Product 1

HCID 136166937HCID 136166937, compound

Procedure

In analogy to example 132, step 6, from (R)-3-(4-chloro-2-methylphenyl)-1-(2-methyl-pyridin-4-yl)-3-(4-(1-(methylsulfonyl)piperidin-4-yl)phenyl)propan-1-one and hydroxylamine hydrochloride in the presence of sodium hydrogencarbonate was prepared the title compound as a white solid, MS (ESI+): m/z=526.3 ([M+H]+).

Sources & evidence

ORD record
ord-2681b1b9310e460ab3d1c653c86cef71
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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