Hydroxyamine hydrochloride → HCID 136360076, compound

HRID 1618003Notes

Reaction equation

HRID 1618003 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH2:9][C:10]([C:12]2[CH:17]=[CH:16][N:15]=[C:14]([CH3:18])[CH:13]=2)=O)=[C:4]([CH3:25])[CH:3]=1.Cl.[NH2:27][OH:28].C(=O)([O-])O.[Na+]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH2:9][C:10]([C:12]2[CH:17]=[CH:16][N:15]=[C:14]([CH3:18])[CH:13]=2)=[N:27][OH:28])=[C:4]([CH3:25])[CH:3]=1

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 66668861HCID 66668861, compound

Product 1

HCID 136360076HCID 136360076, compound

Procedure

In analogy to example 132, step 6, from (S)-3-(4-chloro-2-methylphenyl)-1-(2-methyl-pyridin-4-yl)-3-phenylpropan-1-one and hydroxylamine hydrochloride in the presence of sodium hydrogencarbonate was prepared the title compound as a white solid, MS (ESI+): m/z=365.1 ([M+H]+).

Sources & evidence

ORD record
ord-9daf9950a9694b8aae1665c3a4ce4d3d
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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