Hydroxyamine hydrochloride → HCID 136167042, compound

HRID 1618004Notes

Reaction equation

HRID 1618004 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([C:8](=O)[CH2:9][CH:10]([C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([S:24]([CH3:27])(=[O:26])=[O:25])[CH:19]=2)[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[CH3:17])[CH:5]=[CH:4][N:3]=1.Cl.[NH2:30][OH:31].C(=O)([O-])O.[Na+]>>[CH3:1][C:2]1[CH:7]=[C:6](/[C:8](=[N:30]/[OH:31])/[CH2:9][CH:10]([C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([S:24]([CH3:27])(=[O:26])=[O:25])[CH:19]=2)[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[CH3:17])[CH:5]=[CH:4][N:3]=1

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 66666321HCID 66666321, compound

Product 1

HCID 136167042HCID 136167042, compound

Procedure

In analogy to example 132, step 6, from 1-(2-methylpyridin-4-yl)-3-(3-(methylsulfonyl)-phenyl)-3-o-tolylpropan-1-one and hydroxylamine hydrochloride in the presence of sodium hydrogencarbonate was prepared the title compound as a colourless oil, MS (ESI+): m/z=409.3 ([M+H]+).

Sources & evidence

ORD record
ord-5bfc242a57e04d009612a6e278ff9b18
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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