Hydroxyamine hydrochloride → HCID 136167008, compound

HRID 1618030Notes

Reaction equation

HRID 1618030 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([C:19]2[CH:24]=[CH:23][C:22]([CH:25]3[CH2:30][CH2:29][N:28]([S:31]([NH2:34])(=[O:33])=[O:32])[CH2:27][CH2:26]3)=[CH:21][CH:20]=2)[CH2:9][C:10]([C:12]2[CH:17]=[CH:16][N:15]=[C:14]([CH3:18])[CH:13]=2)=O)=[C:4]([CH3:35])[CH:3]=1.Cl.[NH2:37][OH:38].C(=O)([O-])O.[Na+]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([C:19]2[CH:24]=[CH:23][C:22]([CH:25]3[CH2:30][CH2:29][N:28]([S:31]([NH2:34])(=[O:33])=[O:32])[CH2:27][CH2:26]3)=[CH:21][CH:20]=2)[CH2:9]/[C:10](=[N:37]\[OH:38])/[C:12]2[CH:17]=[CH:16][N:15]=[C:14]([CH3:18])[CH:13]=2)=[C:4]([CH3:35])[CH:3]=1

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 66666614HCID 66666614, compound

Product 1

HCID 136167008HCID 136167008, compound

Procedure

In analogy to example 1, step 2, from (R)-4-(4-(1-(4-chloro-2-methylphenyl)-3-(2-methylpyridin-4-yl)-3-oxopropyl)phenyl)piperidine-1-sulfonamide and hydroxylamine hydrochloride in the presence of sodium hydrogencarbonate was prepared the title compound as a white foam, MS (ESI+): m/z=527.3 ([M+H]+).

Sources & evidence

ORD record
ord-78d2b89bf97d44659115284854bddf22
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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