Hydroxyamine hydrochloride → HCID 136167000, compound

HRID 1618034Notes

Reaction equation

[NH:1]1[CH2:4][CH:3]([C:5]2[CH:10]=[CH:9][C:8]([C@H:11]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=3[CH3:28])[CH2:12][C:13]([C:15]3[CH:20]=[CH:19][N:18]=[C:17]([CH3:21])[CH:16]=3)=O)=[CH:7][CH:6]=2)[CH2:2]1.Cl.[NH2:30][OH:31].C(=O)([O-])O.[Na+]>>[NH:1]1[CH2:4][CH:3]([C:5]2[CH:10]=[CH:9][C:8]([C@H:11]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=3[CH3:28])[CH2:12]/[C:13](/[C:15]3[CH:20]=[CH:19][N:18]=[C:17]([CH3:21])[CH:16]=3)=[N:30]\[OH:31])=[CH:7][CH:6]=2)[CH2:2]1

Participants

Reactant 3

HCID 443297Hydroxyamine hydrochloride

HCID 516892Sodium Bicarbonate

HCID 67015698HCID 67015698, compound

Product 1

HCID 136167000HCID 136167000, compound

Procedure

In analogy to example 1, step 2, from (R)-3-(4-(azetidin-3-yl)phenyl)-1-(2-methylpyridin-4-yl)-3-o-tolylpropan-1-one and hydroxylamine hydrochloride in the presence of sodium hydrogencarbonate was prepared the title compound as a white foam, MS (ESI+): m/z=386.0 ([M+H]+).

Sources & evidence

ORD record: ord-a6b5fb00d0844c5e874d033adc12ebbf
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08765730B2

Reaction notes

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