Hydroxyamine hydrochloride → HCID 136166893, compound

HRID 1618036Notes

Reaction equation

[C:1]([N:4]1[CH2:7][CH:6]([C:8]2[CH:13]=[CH:12][C:11]([C@H:14]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[CH3:31])[CH2:15][C:16]([C:18]3[CH:23]=[CH:22][N:21]=[C:20]([CH3:24])[CH:19]=3)=O)=[CH:10][CH:9]=2)[CH2:5]1)(=[O:3])[CH3:2].Cl.[NH2:33][OH:34].C(=O)([O-])O.[Na+]>>[OH:34]/[N:33]=[C:16](/[C:18]1[CH:23]=[CH:22][N:21]=[C:20]([CH3:24])[CH:19]=1)\[CH2:15][C@H:14]([C:11]1[CH:10]=[CH:9][C:8]([CH:6]2[CH2:5][N:4]([C:1](=[O:3])[CH3:2])[CH2:7]2)=[CH:13][CH:12]=1)[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[CH3:31]

Participants

Reactant 3

HCID 443297Hydroxyamine hydrochloride

HCID 516892Sodium Bicarbonate

HCID 67015710HCID 67015710, compound

Product 1

HCID 136166893HCID 136166893, compound

Procedure

In analogy to example 1, step 2, from (R)-3-(4-(1-acetylazetidin-3-yl)phenyl)-1-(2-methylpyridin-4-yl)-3-o-tolylpropan-1-one and hydroxylamine hydrochloride in the presence of sodium hydrogencarbonate was prepared the title compound as a colourless oil, MS (ESI+): m/z=428.1 ([M+H]+).

Sources & evidence

ORD record: ord-23e8509591b94f7bbec4edeee437a7e4
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08765730B2

Reaction notes

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