Diethyl Malonate → HCID 54579175, compound

HRID 1618101Notes

Reaction equation

HRID 1618101 reaction equation
[CH3:1][CH:2]([CH2:5][CH2:6][C:7]1[C:12]([CH3:14])([CH3:13])[CH2:11][CH2:10][CH2:9][C:8]=1[CH3:15])[CH:3]=O.[C:16]([O:24][CH2:25][CH3:26])(=[O:23])[CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19]>O1CCCC1.ClC(Cl)(Cl)Cl.[Ti](Cl)(Cl)(Cl)Cl>[CH3:1][CH:2]([CH2:5][CH2:6][C:7]1[C:12]([CH3:14])([CH3:13])[CH2:11][CH2:10][CH2:9][C:8]=1[CH3:15])[CH:3]=[C:17]([C:18]([O:20][CH2:21][CH3:22])=[O:19])[C:16]([O:24][CH2:25][CH3:26])=[O:23]

Participants

6

Reactant 2

HCID 7761Diethyl MalonateHCID 5791571-Cyclohexene-1-butanal, .alpha.,2,6,6-tetramethyl-

Product 1

HCID 54579175HCID 54579175, compound

Reagents, catalysts & solvents 3

HCID 24193Titanium TetrachlorideCatalystHCID 5943Carbon TetrachlorideSolventHCID 8028TetrahydrofuranSolvent

Procedure

Under the conditions described in example 1, titanium(IV) chloride (91 g, 0.5 mol), 2-methyl-4-(2,6,6-trimethylcyclohex-1-enyl)butanal 4 (50 g, 0.24 mol) and diethyl malonate (39.7 g, 0.24 mol) in tetrahydrofuran and tetrachloromethane are reacted which each other to give after work-up and short-path-distillation 70.1 g (83%) of 3b. Analytical data: 1H-NMR (400 MHz, CDCl3): δ 0.97 (s, 6 H), 1.1 (d, 3 H), 1.25-1.6 (6 H), 1.3 (2t, 6 H), 1.58 (s, 3 H), 1.8-2.0 (2 H), 2.55 (m, 1 H), 4.15-4.35 (2q, 4 H), 6.8 (d, 1 H) ppm. 13C-NMR (400 MHz, CDCl3): δ 14.0 (q), 14.15 (q), 19.5 (t), 19.6 (q), 19.8 (q), 26.5 (t), 28.5 (q), 32.7 (t), 34.85 (s), 35.6 (d), 36.9 (t), 39.8 (t), 61.1 (t), 61.15 (t), 127.0 (s), 127.5 (s), 136.9 (s), 153.9 (d), 164.0 (s), 165.7 (s). MS (EI): m/z (%) 350 (M+, 4), 335 ([M-15]+, 3), 305 (4), 289 (5), 259 (9), 243 (11), 215 (8), 200 (98), 190 (18), 187 (11), 175 (16), 173 (27), 167 (18), 154 (100), 135 (30), 123 (42), 122 (30), 121 (39), 109 (19), 108 (60), 107 (32), 105 (19), 95 (52), 93 (34), 91 (25), 81 (40), 79 (30), 77 (15), 69 (21), 67 (26), 55 (36), 41 (32), 29 (28). JR (film): 2950 (m), 2960 (m), 2930 (m), 2862 (m), 1725 (s), 1645 (w), 1455 (m), 1375 (m), 1325 (w), 1250 (s), 1222 (s), 1205 (s), 1180 (m), 1170 (m), 1100 (m), 1050 (m), 1030 (m), 950 (w), 865 (w), 800 (w), 765 (w).

Workup

  1. customare reacted which each other
  2. customto give
  3. distillationafter work-up and short-path-distillation 70.1 g (83%) of 3b

Sources & evidence

ORD record
ord-7db6d62d9f9847f080329681d6fd1bac
Source dataset
uspto-grants-2014_07
Patent number
US08765980B2

Reaction notes

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