反应详情

温度

150 °C

Prepared according to procedure L using 6-bromo-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-b]pyridine (200 mg, 0.88 mmol), 4-chloro-7-fluoro-3-methyl-2-(pyridin-2-yl)quinoline (240 mg, 0.88 mmol) and 4.0M solution of HCl in 1,4-dioxane (0.22 mL, 0.88 mmol) in NMP (1.0 mL) and heating at 150° C. for 3 h in the microwave. After purification 4-(6-bromo-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-b]pyridin-1-yl)-7-fluoro-3-methyl-2-(pyridin-2-yl)quinoline was obtained as a yellow film. Mass Spectrum (ESI) m/e=463 [(M+1) (79Br)] and 465 [(M+1) (81Br)].

1. customPrepared
2. customAfter purification 4-(6-bromo-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-b]pyridin-1-yl)-7-fluoro-3-methyl-2-(pyridin-2-yl)quinoline
3. customwas obtained as a yellow film