Phosphorus oxychloride → HCID 67285129, compound

HRID 1618579Notes

Reaction equation

HRID 1618579 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7](O)=[C:8]([CH3:14])[C:9]([CH3:13])=[N:10]2)=[CH:5][C:4]=1[CH3:16].O=P(Cl)(Cl)[Cl:19]>>[Cl:19][C:7]1[C:6]2[C:11](=[CH:12][C:3]([O:2][CH3:1])=[C:4]([CH3:16])[CH:5]=2)[N:10]=[C:9]([CH3:13])[C:8]=1[CH3:14]

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178486796HCID 178486796, compound

Product 1

HCID 67285129HCID 67285129, compound

Procedure

Prepared according to procedure S using 7-methoxy-2,3,6-trimethylquinolin-4-ol (444.7 mg, 2.0 mmol) and POCl3 (2.0 mL, 21.5 mmol) to give 4-chloro-7-methoxy-2,3,6-trimethylquinoline. Mass Spectrum (ESI), m/e=236.1 (M+1).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-3a8b4117e1084932b6df132bfd046879
Source dataset
uspto-grants-2014_07
Patent number
US08765940B2

Reaction notes

Loading…