Ethyl 2-methylacetoacetate → HCID 178493406, compound

HRID 1618583Notes

Reaction equation

HRID 1618583 reaction equation
[CH3:1][O:2][C:3]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:4]=1[NH2:5].C([O:14][C:15](=O)[CH:16]([CH3:20])[C:17]([CH3:19])=O)C>>[CH3:11][O:10][C:8]1[CH:7]=[C:6]2[C:4](=[C:3]([O:2][CH3:1])[CH:9]=1)[N:5]=[C:17]([CH3:19])[C:16]([CH3:20])=[C:15]2[OH:14]

Participants

3

Reactant 2

HCID 701Ethyl 2-methylacetoacetateHCID 176522,4-Dimethoxyaniline

Product 1

HCID 178493406HCID 178493406, compound

Procedure

Prepared according to procedure R using 2,4-dimethoxy aniline (1.99 g, 13.0 mmol), ethyl-2-methyl-acetoacetate (3.7 mL, 26.2 mmol), and PPA (6.78 g, 67.8 mmol) to afford 6,8-dimethoxy-2,3-dimethylquinolin-4-ol. Mass Spectrum (ESI) m/e=234.1 (M+1).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-174fddb71dfa4e1a94464fc6ddea61fc
Source dataset
uspto-grants-2014_07
Patent number
US08765940B2

Reaction notes

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