Phosphorus oxychloride → HCID 54891680, compound

HRID 1618584Notes

Reaction equation

HRID 1618584 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[C:11]([O:13][CH3:14])[CH:12]=1)[N:9]=[C:8]([CH3:15])[C:7]([CH3:16])=[C:6]2O.O=P(Cl)(Cl)[Cl:20]>>[Cl:20][C:6]1[C:5]2[C:10](=[C:11]([O:13][CH3:14])[CH:12]=[C:3]([O:2][CH3:1])[CH:4]=2)[N:9]=[C:8]([CH3:15])[C:7]=1[CH3:16]

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178493406HCID 178493406, compound

Product 1

HCID 54891680HCID 54891680, compound

Procedure

Prepared according to procedure S using 6,8-dimethoxy-2,3-dimethylquinolin-4-ol (1.0 g, 7.0 mmol) and POCl3 (5.0 mL, 53.6 mmol) to afford 4-chloro-6,8-dimethoxy-2,3-dimethylquinoline. Mass Spectrum (ESI) m/e=252.1 (M+1).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-9b3382da02ee467a9dee27d4713d2764
Source dataset
uspto-grants-2014_07
Patent number
US08765940B2

Reaction notes

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