Phosphorus oxychloride → 4,6-Dichloro-2-(2-methoxyphenyl)quinoline

HRID 1618586Notes

Reaction equation

HRID 1618586 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[O:18][CH3:19])[CH:6]=[C:5]2O.O=P(Cl)(Cl)[Cl:23]>>[Cl:23][C:5]1[C:4]2[C:9](=[CH:10][CH:11]=[C:2]([Cl:1])[CH:3]=2)[N:8]=[C:7]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[O:18][CH3:19])[CH:6]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178489314HCID 178489314, compound

Product 1

HCID 672852334,6-Dichloro-2-(2-methoxyphenyl)quinoline

Procedure

Prepared according to procedure S using 6-chloro-2-(2-methoxyphenyl)quinolin-4-ol (550.6 mg, 1.93 mmol) and POCl3 (3.5 mL, 37.5 mmol) to afford 4,6-dichloro-2-(2-methoxyphenyl)quinoline. Mass Spectrum (ESI) m/e=304.0 (M+1).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-eb42c37bfbe2444d9639260ca1288268
Source dataset
uspto-grants-2014_07
Patent number
US08765940B2

Reaction notes

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