反应详情

温度

60 °C

To a suspension of trans-7-chloro-1,2,3,4,10,14b-hexahydro-10-methyldibenzo[b,f]pyrido[1,2-d][1,4]-diazepin-1-ylamine (100 mg, 0.25 mmol) in DMF (2 mL) was added ethyl bromoacetate (56 μl, 0.51 mmol) and triethylamine (107 ul, 0.76 mmol). The resulting reaction mixture was heated to 60° C. and stirred for 5 h. The mixture was poured into water and extracted with ethyl acetate (3×). The organic layers were washed with sat (aq) NaHCO3 and brine. After drying (MgSO4), the solvents were removed under reduced pressure. The crude product was purified on silica with heptane/ethyl acetate 8:2 to afford 80 mg (80%) of the title compound.

1. customThe resulting reaction mixture
2. extractionextracted with ethyl acetate (3×)
3. washThe organic layers were washed
4. dry with materialAfter drying (MgSO4)
5. customthe solvents were removed under reduced pressure
6. customThe crude product was purified on silica with heptane/ethyl acetate 8:2