Phosphorus oxychloride → 4,8-Dichloro-2,3-dimethylquinoline

HRID 1618631Notes

Reaction equation

HRID 1618631 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[C:9]([CH3:12])[C:8]([CH3:13])=[C:7]2O.O=P(Cl)(Cl)[Cl:17]>>[Cl:17][C:7]1[C:6]2[C:11](=[C:2]([Cl:1])[CH:3]=[CH:4][CH:5]=2)[N:10]=[C:9]([CH3:12])[C:8]=1[CH3:13]

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178432245HCID 178432245, compound

Product 1

HCID 596315464,8-Dichloro-2,3-dimethylquinoline

Procedure

Prepared according to procedure S using 8-chloro-2,3-dimethylquinolin-4-ol (1.14 g, 5.49 mmol) in POCl3 (7 mL). The resulting precipitate was collected by filtration to have 4,8-dichloro-2,3-dimethylquinoline. Mass Spectrum (ESI) m/e=227 (M+1).

Workup

  1. customPrepared
  2. filtrationThe resulting precipitate was collected by filtration

Sources & evidence

ORD record
ord-f112101a30b648baac5f89a0e5a09489
Source dataset
uspto-grants-2014_07
Patent number
US08765940B2

Reaction notes

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