Sodium Carbonate → HCID 67285251, compound

HRID 1618764Notes

Reaction equation

HRID 1618764 reaction equation
Cl[C:2]1[C:11]([CH3:12])=[C:10]([Cl:13])[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[C:14]1(B(O)O)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.C(=O)([O-])[O-].[Na+].[Na+]>C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[Cl:13][C:10]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[N:3]=[C:2]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:11]=1[CH3:12]

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 66827Phenylboronic AcidHCID 220826612,4-Dichloro-3-methyl-1,8-naphthyridine

Product 1

HCID 67285251HCID 67285251, compound

Reagents, catalysts & solvents 1

HCID 178418397HCID 178418397, compoundCatalyst

Procedure

Prepared according to procedure F using 2,4-dichloro-3-methyl-1,8-naphthyridine (150 mg, 0.704 mmol), phenylboronic acid (86 mg, 0.704 mmol), sodium carbonate (149 mg, 1.408 mmol) and Pd(PPh3)4. Product used without further purification in the next step. Mass Spectrum (ESI) m/e=255.0 (M+1).

Workup

  1. customPrepared
  2. customProduct used without further purification in the next step

Sources & evidence

ORD record
ord-664cd460c72544a79f4932dc698a8595
Source dataset
uspto-grants-2014_07
Patent number
US08765940B2

Reaction notes

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