反应详情

温度

60 °C

To a solution of 1-acetyl-6-(4-morpholinyl)-1,2-dihydrospiro[indole-3,3′-thietane]1′,1′-dioxide (0.046 g, 0.137 mmol) in MeOH (1.367 mL) was added 5.0N HCl solution (0.27 mL, 1.37 mmol). The solution was stirred at 60° C. for 3 h and then it was cooled to rt and poured into saturated aqueous NaHCO3 and extracted with DCM. The organic extracts were dried over MgSO4 and evaporated in vacuo to give 6-(4-morpholinyl)-1,2-dihydrospiro[indole-3,3′-thietane]1′,1′-dioxide as a brown solid. Mass Spectrum (ESI) m/e=295.1 (M+1).

1. temperatureit was cooled to rt
2. extractionextracted with DCM
3. dry with materialThe organic extracts were dried over MgSO4
4. customevaporated in vacuo