1,1-Dimethoxyethyl(dimethyl)amine → HCID 178464895, compound

HRID 1619136Notes

Reaction equation

HRID 1619136 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([I:12])[C:10]=1[CH3:11])[C:5]([NH2:7])=[O:6].CO[C:15]([N:19]([CH3:21])[CH3:20])(OC)[CH3:16]>>[CH3:20][N:19]([CH3:21])/[C:15](=[N:7]/[C:5](=[O:6])[C:4]1[CH:8]=[C:9]([I:12])[C:10]([CH3:11])=[C:2]([F:1])[CH:3]=1)/[CH3:16]

Participants

3

Reactant 2

HCID 878351,1-Dimethoxyethyl(dimethyl)amineHCID 58170464HCID 58170464, compound

Product 1

HCID 178464895HCID 178464895, compoundYield 100%

Conditions

Temperature
120 °C

Procedure

A mixture of 3-fluoro-5-iodo-4-methylbenzamide (preparation 50b) and (1,1-dimethoxyethyl)dimethylamine was heated at 120° C. in a sealed tube. After 2 hours, the reaction mixture was cooled and the solvent was evaporated under reduced pressure to give the title compound (1.84 g, 100%) as an oil.

Workup

  1. temperaturethe reaction mixture was cooled
  2. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-35180b23496b4f0a89d5e1d6527c36fe
Source dataset
uspto-grants-2014_07
Patent number
US08772288B2

Reaction notes

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