Methanol → HCID 58574125, compound

HRID 1619307Notes

Reaction equation

HRID 1619307 reaction equation
C1(S(O[CH:11]2[N:23]3[C:14](=[N:15][C:16]4[CH:17]=[C:18]([Br:25])[CH:19]=[CH:20][C:21]=4[C:22]3=[O:24])[CH2:13][CH2:12]2)(=O)=O)C=CC=CC=1.[C:26](=[O:29])([O-])[O-].[K+].[K+].[CH3:32]O>>[Br:25][C:18]1[CH:19]=[CH:20][C:21]2[C:22](=[O:24])[N:23]3[CH:11]([CH2:32][O:29][CH3:26])[CH2:12][CH2:13][C:14]3=[N:15][C:16]=2[CH:17]=1

Participants

4

Reactant 3

HCID 887MethanolHCID 11430Potassium CarbonateHCID 86660654HCID 86660654, compound

Product 1

HCID 58574125HCID 58574125, compound

Procedure

A solution of 6-bromo-9-oxo-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazolin-1-yl benzenesulfonate (300 mg, 0.69 mmol) and potassium carbonate (290 mg, 2.1 mmol) in methanol (80 mL) was stirred at reflux for 2 h. After it was cooled to room temperature, the mixture was concentrated and purified by silica-gel chromatography to give the desired product. MS (ESI): 309, 311 (MH+).

Workup

  1. temperatureat reflux for 2 h
  2. concentrationthe mixture was concentrated
  3. custompurified by silica-gel chromatography

Sources & evidence

ORD record
ord-3aa9a783476d4130b92f28557c0e49ca
Source dataset
uspto-grants-2014_07
Patent number
US08772301B2

Reaction notes

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