2-Bromobutane → HCID 58574575, compound

HRID 1619334Notes

Reaction equation

HRID 1619334 reaction equation
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:16])[N:7]3[CH2:15][CH2:14][NH:13][CH2:12][C:8]3=[N:9]2)=[CH:4][CH:3]=1.Br[CH:18]([CH2:20][CH3:21])[CH3:19]>CN(C=O)C>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:16])[N:7]3[CH2:15][CH2:14][N:13]([CH:18]([CH2:20][CH3:21])[CH3:19])[CH2:12][C:8]3=[N:9]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 65542-BromobutaneHCID 58574180HCID 58574180, compound

Product 1

HCID 58574575HCID 58574575, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 9-bromo-3,4-dihydro-1H-pyrazino[2,1-b]quinazolin-6(2H)-one (30 mg, 0.11 mmol) and excess 2-bromobutane in DMF (5 mL) was stirred at 140° C. for 6 h. Then the reaction mixture was concentrated and purified by column chromatography to give the desired product. MS (ESI): 336, 338 (MH+).

Workup

  1. concentrationThen the reaction mixture was concentrated
  2. custompurified by column chromatography

Sources & evidence

ORD record
ord-c1d3517650bf49e6846dd5c7847ed9e2
Source dataset
uspto-grants-2014_07
Patent number
US08772301B2

Reaction notes

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