Ethyl 2-(1-amino-2-methylpropan-2-ylamino)acetate → 5,5-Dimethylpiperazin-2-one

HRID 1619337Notes

Reaction equation

HRID 1619337 reaction equation
[NH2:1][CH2:2][C:3]([NH:6][CH2:7][C:8]([O:10]CC)=O)([CH3:5])[CH3:4]>CN(C=O)C>[CH3:4][C:3]1([CH3:5])[CH2:2][NH:1][C:8](=[O:10])[CH2:7][NH:6]1

Participants

3

Reactant 1

HCID 58574370Ethyl 2-(1-amino-2-methylpropan-2-ylamino)acetate

Product 1

HCID 233196555,5-Dimethylpiperazin-2-one

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of ethyl 2-(1-amino-2-methylpropan-2-ylamino)acetate (0.8 g, 4.7 mmol) in DMF (20 mL) was stirred at reflux for 1 h. After it was cooled to room temperature, the mixture was concentrated to give the crude product, which was directly used for the next step. MS (ESI): 129 (MH+).

Workup

  1. temperatureat reflux for 1 h
  2. concentrationthe mixture was concentrated

Sources & evidence

ORD record
ord-93d3cf467db04cf9a0201c04cb14507c
Source dataset
uspto-grants-2014_07
Patent number
US08772301B2

Reaction notes

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