反应详情

A solution of 7-bromo-2-(pyrrolidin-2-yl)quinazolin-4(3H)-one (158 mg, 0.49 mmol), K2CO3 (0.5 g, 3.6 mmol), a catalytic amount of NaI, and 1-bromo-2-chloroethane (70 mg, 0.49 mmol) in CH3CN was stirred at 80° C. overnight. After dilution with H2O (30 mL), the mixture was extracted with ethyl acetate (3×100 mL). Then the combined organic layers were dried over Na2SO4 and concentrated to give crude product. After purified by column chromatography, 46 mg of the desired product was obtained. MS (ESI): 320, 322 (MH+)

1. extractionAfter dilution with H2O (30 mL), the mixture was extracted with ethyl acetate (3×100 mL)
2. dry with materialThen the combined organic layers were dried over Na2SO4
3. concentrationconcentrated
4. customto give crude product
5. customAfter purified by column chromatography