Potassium Carbonate → HCID 58574323, compound

HRID 1619397Notes

Reaction equation

HRID 1619397 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][CH:2]1[CH2:6][CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9].Br[CH2:14][C:15]([O:17][CH3:18])=[O:16].C([O-])([O-])=O.[K+].[K+]>CC#N.O>[CH3:18][O:17][C:15](=[O:16])[CH2:14][N:1]1[CH2:5][CH2:4][CH2:3][CH:2]1[CH2:6][CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9]

Participants

6

Reactant 3

HCID 11430Potassium CarbonateHCID 60984Methyl bromoacetateHCID 21600119Ethyl 2-pyrrolidinepropanoate

Product 1

HCID 58574323HCID 58574323, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6342AcetonitrileSolvent

Procedure

A solution of ethyl 3-(pyrrolidin-2-yl)propanoate (3 g, 17.5 mmol), methyl 2-bromoacetate (3 g, 18 mmol) and K2CO3 (3 g, 21.7 mmol) in CH3CN was stirred at 80° C. overnight. The completion of the reaction was monitored by TLC. After the suspension was diluted with water (50 mL) and extracted with ethyl acetate (3×50 mL), the combined organic layers were concentrated to give the crude product, which was directly used for the next step without further purification. MS (ESI): 244 (MH+).

Workup

  1. extractionextracted with ethyl acetate (3×50 mL)
  2. concentrationthe combined organic layers were concentrated

Sources & evidence

ORD record
ord-0d41c8e910674cc9a2c3ca301f864dc3
Source dataset
uspto-grants-2014_07
Patent number
US08772301B2

Reaction notes

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