Hydrochloric Acid → HCID 58574349, compound

HRID 1619431Notes

Reaction equation

HRID 1619431 reaction equation
[O:1]=[C:2]1[N:7]2[CH:8]=[CH:9][C:10]([C:12]([O:14]C)=[O:13])=[CH:11][C:6]2=[N:5][C:4]2[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][C:3]1=2.O[Li].O.Cl>CO>[O:1]=[C:2]1[N:7]2[CH:8]=[CH:9][C:10]([C:12]([OH:14])=[O:13])=[CH:11][C:6]2=[N:5][C:4]2[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][C:3]1=2

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 168937Lithium hydroxide, monohydrateHCID 58574225HCID 58574225, compound

Product 1

HCID 58574349HCID 58574349, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of methyl 12-oxo-7,8,9,10,11,12-hexahydro-6H-cycloocta[d]pyrido[1,2-a]-pyrimidine-3-carboxylate (80 mg, 0.28 mmol) and LiOH H2O in MeOH (5 mL) was stirred at room temperature for 0.5 h. The reaction mixture was adjusted to pH around 6 with 1 N HCl and extracted with ethyl acetate (2×25 mL). The combined ethyl acetate layers were washed with brine and dried over anhydrous sodium sulfate. After filtration and concentration, the crude product was used for the next step without further purification.

Workup

  1. extractionextracted with ethyl acetate (2×25 mL)
  2. washThe combined ethyl acetate layers were washed with brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. filtrationAfter filtration and concentration
  5. customthe crude product was used for the next step without further purification

Sources & evidence

ORD record
ord-204a9bfc39ac4892806ce3f89301449a
Source dataset
uspto-grants-2014_07
Patent number
US08772301B2

Reaction notes

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