HCID 68296659, compound → HCID 68296793, compound

HRID 1619450Notes

Reaction equation

HRID 1619450 reaction equation
[CH3:1][N:2]([CH3:18])[C:3]([C:5]1[NH:6][C:7]2[C:12]([CH:13]=1)=[CH:11][C:10]([N+:14]([O-])=O)=[CH:9][C:8]=2[Cl:17])=[O:4].[H][H]>[Pt].O1CCCC1>[CH3:1][N:2]([CH3:18])[C:3]([C:5]1[NH:6][C:7]2[C:12]([CH:13]=1)=[CH:11][C:10]([NH2:14])=[CH:9][C:8]=2[Cl:17])=[O:4]

Participants

5

Reactant 2

HCID 68296659HCID 68296659, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 68296793HCID 68296793, compound

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 2.6 g I.7 (7-chloro-5-nitro-1H-indole-2-carboxylic acid dimethylamide), 0.3 g Pt/C 10%, 10 ml methanol and 90 ml tetrahydrofuran was stirred ambient temperature under a pressure of 50 psi hydrogen. The catalyst was filtered and the solvent was evaporated. The resulting crude material was used for the next step without purification.

Workup

  1. filtrationThe catalyst was filtered
  2. customthe solvent was evaporated
  3. customThe resulting crude material was used for the next step without purification

Sources & evidence

ORD record
ord-9b50b84946204377a74dc87b20c6208c
Source dataset
uspto-grants-2014_07
Patent number
US08772305B2

Reaction notes

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