HCID 53399353, compound → HCID 68296580, compound

HRID 1619454Notes

Reaction equation

HRID 1619454 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N+:15]([O-])=O)[CH:6]=[C:7]2[C:11]=1[NH:10][C:9]([C:12]([OH:14])=[O:13])=[CH:8]2.[H][H]>CO.O1CCCC1.[Pd]>[NH2:15][C:5]1[CH:6]=[C:7]2[C:11](=[C:3]([O:2][CH3:1])[CH:4]=1)[NH:10][C:9]([C:12]([OH:14])=[O:13])=[CH:8]2

Participants

6

Reactant 2

HCID 53399353HCID 53399353, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 68296580HCID 68296580, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 472 mg 7-methoxy-5-nitro-1H-indole-2-carboxylic acid and 0.1 g Pd/C 10% in 10 ml methanol and 20 ml tetrahydrofuran was stirred for 2 h at ambient temperature under a pressure of 3 bar of hydrogen. The catalyst was filtered and the filtrate was evaporated to obtain brown solid.

Workup

  1. filtrationThe catalyst was filtered
  2. customthe filtrate was evaporated
  3. customto obtain brown solid

Sources & evidence

ORD record
ord-2df76852a88b4016b4c1ff9aed1d7e1f
Source dataset
uspto-grants-2014_07
Patent number
US08772305B2

Reaction notes

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