Cyanamide → HCID 178480887, compound

HRID 1619456Notes

Reaction equation

HRID 1619456 reaction equation
[ClH:1].[NH2:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[CH2:8][N:7]([CH2:12][CH2:13][N:14]1[CH2:18][CH2:17][N:16]([CH3:19])[C:15]1=[O:20])[CH2:6]2.[N:21]#[C:22][NH2:23]>O1CCOCC1.Cl>[ClH:1].[CH3:19][N:16]1[CH2:17][CH2:18][N:14]([CH2:13][CH2:12][N:7]2[CH2:6][C:5]3[C:9](=[CH:10][CH:11]=[C:3]([NH:2][C:22]([NH2:23])=[NH:21])[CH:4]=3)[CH2:8]2)[C:15]1=[O:20]

Participants

5

Reactant 2

HCID 9864CyanamideHCID 68296532HCID 68296532, compound

Product 1

HCID 178480887HCID 178480887, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent2×

Procedure

0.4 g I.21 (1-[2-(5-amino-1,3-dihydro-isoindol-2-yl)-ethyl]-3-methyl-imidazolidin-2-one hydrochloride) was added to a mixture of 0.37 g cyanamide in 3 ml dioxane and 1 ml 4 N hydrochloric acid in dioxane. The mixture was irradiated at 140° C. in a microwave for 30 min. The solvent was evaporated and the residue was used in the next step without purification.

Workup

  1. customThe mixture was irradiated at 140° C. in a microwave for 30 min
  2. customThe solvent was evaporated
  3. customthe residue was used in the next step without purification

Sources & evidence

ORD record
ord-97bf161551ad4b59a900b19e2edb6a09
Source dataset
uspto-grants-2014_07
Patent number
US08772305B2

Reaction notes

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