Phosphorus oxychloride → HCID 86675897, compound

HRID 1619457Notes

Reaction equation

HRID 1619457 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]2[CH:13]=[CH:12][N:11]=[C:10](O)[N:9]=2)[CH:3]=1.P(Cl)(Cl)([Cl:17])=O>>[Cl:17][C:10]1[N:9]=[C:8]([C:4]2[CH:3]=[C:2]([Cl:1])[CH:7]=[CH:6][N:5]=2)[CH:13]=[CH:12][N:11]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178517733HCID 178517733, compound

Product 1

HCID 86675897HCID 86675897, compound

Procedure

A mixture of 10 g I.28 (4-(4-chloro-pyridin-2-yl)-pyrimidin-2-ol) in 100 ml phosphorus oxychloride was stirred for 3 h at reflux. The solvent was evaporated and the crude 8.1 was used in the next step without purification.

Workup

  1. temperatureat reflux
  2. customThe solvent was evaporated
  3. customthe crude 8.1 was used in the next step without purification

Sources & evidence

ORD record
ord-14de2c354341478a982e74fc897a7228
Source dataset
uspto-grants-2014_07
Patent number
US08772305B2

Reaction notes

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