反应详情

To a solution of (R)-quinuclidin-3-yl 2-(cyclohexyloxycarbonylamino)-2-phenylacetate (C38) (105 mg, 0.27 mmol) in EtOAc (3 ml), was added 2-bromo-1-phenylethanone (59.5 mg, 0.30 mmol). The reaction was stirred at RT for 15 hours, and then the solvent was evaporated. The crude was purified by flash chromatography (DCM/MeOH=95/5 to 93/7) to obtain (3R)-3-(2-(cyclohexyloxycarbonylamino)-2-phenylacetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane bromide (83.8 mg; 53% yield).

1. customthe solvent was evaporated
2. customThe crude was purified by flash chromatography (DCM/MeOH=95/5 to 93/7)